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Semaphorin Linked to Lung Cancer Treatment Resistance

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EGFR mutation is a specific risk factor for developing lung cancer which is one of the primary cause of mortality across the globe. The mechanism behind the emergence of resistance to otherwise effective treatments has remained unclear. In a new study reported in the journal iJCI Insight/i, researchers at Osaka University have revealed the importance of a protein called Semaphorin 7a in resistance to an important class of cancer drugs called EGFR-TKIs in mutated cells in adenocarcinoma, the most common form of lung cancer....

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