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Mechanism of Resistance to Lung Cancer Drug Discovered

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For treating cancer, drugs like tyrosine kinase inhibitors are sometimes used. Osimertinib is one of the tyrosine kinase inhibitors used to treat EGFR-mutated lung cancer with a certain degree of efficacy. (EGFR refers to "epidermal growth factor receptor", a protein which plays an important role in signaling from the extracellular environment to a cell.) However, in some patients, intrinsic resistance and inadequate response to osimertinib has been seen to occur. Seiji Yano from Kanazawa University ...

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